Epiregulin Protein (EREG)

Produktnummer ABIN987824

Dieses Epiregulin-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für Epiregulin Protein (EREG) (ABIN987824)

Target: Epiregulin (EREG)

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 97 % by SDS-PAGE and HPLC analyses.

Produktdetails

Sequenz: MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFF

Produktmerkmale: Fully biologically active when compared to standard. The ED50 was determined by the dose-dependent stimulation of the proliferation of mouse Balb/3T3 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of≥ 5×105units/mg.

Endotoxin-Niveau: Level Less than 1EU/µg of rHuEREG as determined by LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Lagerung: 4 °C

Antigendetails

Target: Epiregulin (EREG)

Hintergrund: Epiregulin is a member of the EGF family of growth factors which includes, among others, epidermal growth factor (EGF), transforming growth factor (TGF)-alpha, amphiregulin (ARG), HB (heparin-binding)-EGF, betacellulin, and the various heregulins. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence. Synonym: Epiregulin (EREG), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH7.4, 130mM NaCl.

Molekulargewicht: Approximately 6.0 KDa, a single non-glycosylated polypeptide chain containing 50 amino acids.

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation