Thrombopoietin Protein (THPO)

Produktnummer ABIN935857

Recombinant Thrombopoietin-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für Thrombopoietin Protein (THPO) (ABIN935857)

Target: Thrombopoietin (THPO)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 98 % pure

Produktdetails

Sequenz: SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF

Produktmerkmale: Purified recombinant Human Thrombopoietin protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be 1 x 10^6 units/mg.

Endotoxin-Niveau: < 0.1 ng per µg (1 EU/µg).

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Restore in water to a concentration of 0.5 - 1.0 mg/mL.

Buffer: Lyophilized from 10 mM Tris, pH 8.0.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Antigendetails

Target: Thrombopoietin (THPO)

Andere Bezeichnung: Thrombopoietin

Hintergrund: TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and Mouse TPO exhibits cross-species reactivity.
Alternative Names: c-MPL Ligand protein, TPO protein, THPO protein, Megakaryocyte colony-stimulating factor protein, MGDF protein

Molekulargewicht: 18.7 kDa

Pathways: JAK-STAT Signalweg, Hormone Activity