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SERPINB2 Protein

Recombinant SERPINB2-Protein exprimiert in Escherichia coli (E. coli).
Produktnummer ABIN935740

Kurzübersicht für SERPINB2 Protein (ABIN935740)

Target

Alle SERPINB2 Proteine anzeigen
SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 11
  • 4
  • 4
  • 2
Human

Quelle

  • 12
  • 4
  • 2
  • 1
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 95 % pure
  • Sequenz

    MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA MVYMGSRGST EDQMAKVLQF NEVGANAVT PMTPENFTSC GFMQQIQKGS YPDAILQAQA ADKIHSSFRS LSSAINASTG N YLLESVNK LFGEKSASFR EEYIRLCQKY YSSEPQAVDF LECAEEARKK INSWVKTQTK GK IPNLLPE GSVDGDTRMV LVNAVYFKGK WKTPFEKKLN GLYPFRVNSA QRTPVQMMYL REK LNIGYI EDLKAQILEL PYAGDVSMFL LLPDEIADVS TGLELLESEI TYDKLNKWTS KDKM AEDEV EVYIPQFKLE EHYELRSILR SMGMEDAFNK GRANFSGMSE RNDLFLSEVF HQAMV DVNE EGTEAAAGTG GVMTGRTGHG GPQFVADHPF LFLIMHKITN CILFFGRFSS P

    Produktmerkmale

    Purified recombinant Human PAI2 protein
    Expression System: E.coli
    Bioactivity: Determined by its inhibitory effect against single chain tPA induced cleavage of a chromogenic substrate in Imidazole Buffer at 370C. Half maximal inhibition against 1.0 µg/mL of single chain tPA was obtained at a concentration of 1.0 µg/mL

    Endotoxin-Niveau

    < 0.1 ng per µg (1 EU/µg).
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    Produkt
    Expressionssystem
    Konjugat
    Origin
    Preis ab
    Expressionssystem HEK-293 Cells
    Konjugat His tag
    Origin Human
    Preis ab 13.711,36 €
    Expressionssystem Cell-free protein synthesis (CFPS)
    Konjugat Strep Tag
    Origin Human
    Preis ab 18.117,43 €

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  • Applikationshinweise

    Each Investigator should determine their own optimal working dilution for specific applications.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Reconstitute in water to a concentration of 0.1-1.0 mg/mL.

    Buffer

    Lyophilized from 50 MM CH3COONa, with 100 mM NaCl.

    Handhabung

    Avoid repeated freeze/thaw cycles.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
  • Target

    SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

    Andere Bezeichnung

    PAI2

    Substanzklasse

    Amino Acid

    Hintergrund

    PAI-2 is an inhibitory serpin expressed mainly in keratinocytes, activated monocytes, and placental trophoblasts. It exists predominantly as a 47 kDa nonglycosylated intracellular protein which can be induced to be secreted as 60 kDa glycoprotein. The glycosylated and unglycosylated forms of PAI-2 are equally effective as inhibitors of urokinase-type plasminogen activator (uPA), the only established physiological target of this serpin. PAI-2 has a unique ability to form dormant polymers spontaneously and reversibly under physiological conditions.
    Alternative Names: Plasminogen Activator Inhibitor-2 protein, Urokinase Inhibitor protein, PAI 2, PAI-2 protein, PAI2, PAI-2 protein, PAI 2 protein, PAI-2

    Pathways

    Autophagie
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