Interferon gamma Protein (IFNG)

Produktnummer ABIN935524

Produktdetails

Target: Interferon gamma (IFNG)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Sequenz: MQGTLIESLE SLKNYFNSSS MDAMEGKSLL LDIWRNWQKD GNTKILESQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT NFFSNSKAKK DAFMSIAKFE VNNPQIQHKA VNELIRVIHQ LSPESSLRKR KRSRC

Produktmerkmale: Purified recombinant Human IFN gamma protein
Expression System: E.coli
Bioactivity: The ED50 as determined by a cytopathic affect inhibition assay with Mouse L929 cells challenged with EMC virus was 1 x 10^7 units/mg.

Reinheit: > 98 % pure

Endotoxin-Niveau: < 0.1 ng per µg (1 EU/µg).

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 10 mM Na0 O4 pH7.2 to a concentration of 0.1-1.0 mg/mL. When dissolved, dilute further into aqueous buffered solutions.

Buffer: Lyophilized from 10 mM Na3PO4, pH7.2.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: RT/-20 °C

Referenzen

POGO, BRAWERMAN, CHARGAFF: "New ribonucleic acid species associated wihin the formation of the photosynthetic apparatus in Euglena gracilis." in: Biochemistry, Vol. 1, pp. 128-31 (PubMed).

Antigendetails

Target: Interferon gamma (IFNG)

Andere Bezeichnung: IFN gamma (IFNG Produkte)

Synonyme: IFG Protein, IFI Protein, IFN-g Protein, Ifg Protein, IFNG2 Protein, IFN-gamma Protein, IFN-G Protein, IFNG Protein, IFNgamma Protein, TCRalpha Protein, INF-G Protein, ifng Protein, interferon gamma Protein, interferon, gamma 1-2 Protein, IFNG Protein, Ifng Protein, ifng1-2 Protein

Hintergrund: IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells, which respond to IFN-gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-gamma signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-gamma stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-gamma is species-specific and is biologically active only in human and primate cells.
Alternative Names: IFN g protein, Immune Interferon protein, T cell interferon protein, IFN-g protein, MAF protein, type II interferon protein, Interferon gamma protein

Molekulargewicht: 15.6 kDa

Pathways: Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagie