Epiregulin Protein (EREG)
Kurzübersicht für Epiregulin Protein (EREG) (ABIN935331)
Target
Alle Epiregulin (EREG) Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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Sequenz
- MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL
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Produktmerkmale
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Purified recombinant Human Epiregulin protein
Expression System: E.coli
Bioactivity: The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse Balb/3T3 cells is ? 2.0 ng/mL, corresponding to a specific activity of ? 5 x 10^5units/mg. -
Endotoxin-Niveau
- < 0.1 ng per µg (1 EU/µg).
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Epiregulin (EREG) (AA 56-101) protein (Fc Tag)
EREG Spezies: Maus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epiregulin (EREG) (AA 63-108) protein (Fc Tag)EREG Spezies: Human Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Epiregulin (EREG) (AA 60-108) protein (His-IF2DI Tag)EREG Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Epiregulin (EREG) (AA 1-169) protein (GST tag)EREG Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handhabung
- Avoid repeated freeze/thaw cycles.
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Lagerung
- RT/-20 °C
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- Epiregulin (EREG)
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Andere Bezeichnung
- Epiregulin
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Hintergrund
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Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
Alternative Names: EREG protein -
Molekulargewicht
- 5.6 kDa
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Pathways
- RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation
Target
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