Caspase 2 Protein
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- Target Alle Caspase 2 (CASP2) Proteine anzeigen
- Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Produktmerkmale
- ~10,000 units/mg. One unit cleaves 1nmole of the caspase substrate VDVAD-pNA per hour at 37°C in a reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT.
- Top Product
- Discover our top product CASP2 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Reconstitute with PBS to 1 unit/µl.
- Lagerung
- -80 °C
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- Target
- Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
- Andere Bezeichnung
- Caspase-2 (CASP2 Produkte)
- Synonyme
- xCaspase-2 Protein, Caspase-2 Protein, ICH-1 Protein, Nedd2 Protein, CASP-2 Protein, ICH1 Protein, NEDD-2 Protein, NEDD2 Protein, PPP1R57 Protein, ICH-1L/1S Protein, ICH1L1S Protein, caspase 2 Protein, caspase 2 L homeolog Protein, caspase-2 Protein, CASP2 Protein, casp2.L Protein, CpipJ_CPIJ008254 Protein, Casp2 Protein
- Hintergrund
- Caspase-2 (also known as Ich-1, Nedd-2) is a member of the interleukin-1 converting enzyme (ICE) family of cysteine proteases. Similar as other caspases, caspase-2 also exists in cells as an inactive proenzyme. During apoptosis, procaspase-2 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed form of caspase-2 consists of large (19 kDa) and small (12 kDa) subunits, which associate to form the active enzyme. The active recombinant human caspase-2 was expressed in E. coli. The expressed caspase-2 spontaneously undergoes auto-processing to yield the subunits characteristic of the native enzyme.
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose, Neurotrophin Signalübertragung
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