Neuregulin 1 Protein (NRG1) (AA 176-246)

Produktnummer ABIN8057047

Dieses Recombinant Neuregulin 1-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für Neuregulin 1 Protein (NRG1) (AA 176-246) (ABIN8057047)

Target: Neuregulin 1 (NRG1)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 176-246

Verwendungszweck: Recombinant Human Pro-Neuregulin-1/NRG1-β1 Protein (aa 176-246)

Sequenz: Thr176-Lys246

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Neuregulin 1 (NRG1)

Andere Bezeichnung: Pro-Neuregulin-1

Hintergrund: EGF,GGF,HGL,HRG1-beta 1,HRGA,NDF,NRG1,NRG1-beta 1,Neuregulin-1 beta 1,Pro-neuregulin-1,SMDF,neuregulin-1 (heregulin-1,NRG1) is a member of neuregulin family, which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.

Molekulargewicht:

Calculated MW: 8.2 kDa

Observed MW: 7 kDa

Gen-ID: 3084

UniProt: Q02297

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation