UBE2C Protein

Produktnummer ABIN7939679

Recombinant UBE2C-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für UBE2C Protein (ABIN7939679)

Target: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant UBE2C protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant UBE2C protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Antigendetails

Target: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Andere Bezeichnung: UBE2C

Hintergrund:

Protein Background: UBE2C (Ubiquitin-conjugating enzyme E2 C) also known as dJ447F3.2 and UBCH10. UBE2C is a member of the E2 ubiquitin-conjugating enzyme family which is required for post-replicative DNA damage repair and plays an important role in various cellular processes. UBE2C can accept ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Short Description: Recombinant UBE2C protein that includes full length of human UBE2C protein (accession number NP_008950.1) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 21.82 kDa. The purity of the protein is ≥ 90 % by SDS-PAGE.

Aliases: Ubiquitin conjugating enzyme E2 C, dj447F3.2, UBCH10

Pathways: Ubiquitin Proteasome Pathway