SMAD2 Protein

Produktnummer ABIN7939588

Dieses Recombinant SMAD2-Protein wird in Baculovirus infected Insect Cells exprimiert.

Kurzübersicht für SMAD2 Protein (ABIN7939588)

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant SMAD2 protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant SMAD2 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Andere Bezeichnung: SMAD2

Hintergrund:

Protein Background: The transforming growth factor-beta (TGF-b) superfamily signaling controls a wide variety of biological processes from development to pathogenesis primarily through intracellular Smad proteins. Smads are structurally and functionally grouped into three subfamilies: five receptor-activated Smads (R-Smads), one common Smad and two inhibitory Smads. Of R-Smads, Smad2 and Smad3 (Smad2/3 thereafter for simplicity) transduce activin and TGF-b signals, whereas Smad1, Smad5 and Smad8 transduce signals from the BMP/GDF (Bone Morphogenetic Proteins/ Growth Differentiation Factor) family. SMAD2 is key intracellular signal transducers for TGF-b signaling and their transcriptional activities are controlled through reversible phosphorylation and nucleocytoplasmic shuttling.

Short Description: Recombinant SMAD2 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_005892.1) with an N-terminal FLAG tag. The molecular weight of SMAD1 is 53.58 kDa.

Aliases: SMAD family member 2, MADR2, MADH2, Mothers Against Decapentaplegic Homolog 2, HMAD-2

Pathways: Zellzyklus, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus