EPH Receptor B3 Protein (EPHB3) (AA 585-998)

Produktnummer ABIN7938805

Dieses Recombinant EPH Receptor B3-Protein wird in Baculovirus infected Insect Cells exprimiert.

Kurzübersicht für EPH Receptor B3 Protein (EPHB3) (AA 585-998) (ABIN7938805)

Target: EPH Receptor B3 (EPHB3)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Screening Assay (ScA), Functional Studies (Func), Activity Assay (AcA)

Produktdetails

Proteineigenschaft: AA 585-998

Verwendungszweck: Recombinant EPHB3 (585-998) protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant EPHB3 (585-998) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100 and 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: EPH Receptor B3 (EPHB3)

Andere Bezeichnung: EPHB3

Hintergrund:

Protein Background: EPHB3(Ephrin type-B receptor 3) is a receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally, has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.

Short Description: Recombinant EPHB3 (585-998) protein that includes amino acids 585-998 of human EPHB3 protein (accession number NP_004434.2) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.19 kDa.

Aliases: Ephrin type-B receptor 3, EPH Receptor B3, HEK2, TYRO6, ETK2, Tyrosine-Protein Kinase TYRO6, EK2, Tyro6, EphB3, Hek2

Pathways: RTK Signalweg