CDKN2B Protein

Produktnummer ABIN7938742

Recombinant CDKN2B-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für CDKN2B Protein (ABIN7938742)

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant CDKN2B protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant CDKN2B protein is supplied in 25 mM Tris-HCl pH 8.0, 300 mM NaCl, 10 % glycerol and 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Andere Bezeichnung: CDKN2B

Hintergrund:

Protein Background: CDKN2B(Cyclin-dependent kinase 4 inhibitor B,This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclindependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Short Description: Recombinant CDKN2B protein that includes full length of human CDKN2B protein (accession number NP_004927.2) was expressed was expressed in E. coli cells with an N-terminal GST tag. The molecular weight of the protein is 41.55 kDa.

Aliases: Cyclin dependent kinase Inhibitor 2B, MTS2, INK4B, CDK4I, TP15, P15, P15 CDK Inhibitor

Pathways: Zellzyklus, Mitotic G1-G1/S Phases