beta Catenin Protein

Produktnummer ABIN7938678

Dieses Recombinant beta Catenin-Protein wird in Baculovirus infected Insect Cells produziert.

Kurzübersicht für beta Catenin Protein (ABIN7938678)

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant beta-Catenin protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant beta-Catenin protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Andere Bezeichnung: beta-Catenin

Hintergrund:

Protein Background: beta-Catenin is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.

Short Description: Recombinant beta-Catenin protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_001091679.1) with an N-terminal FLAG tag. The molecular weight of beta-Catenin is 86.79 kDa.

Aliases: CTNNB1, catenin beta 1, armadillo, CTNNB, NEDSDV, MRD19, EVR7

Pathways: Peptide Hormone Metabolism