MERTK Protein (AA 528-999)

Produktnummer ABIN7938666

Dieses Recombinant MERTK-Protein wird in Baculovirus infected Insect Cells produziert.

Kurzübersicht für MERTK Protein (AA 528-999) (ABIN7938666)

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Activity Assay (AcA), Screening Assay (ScA), Functional Studies (Func)

Produktdetails

Proteineigenschaft: AA 528-999

Verwendungszweck: Recombinant MER (528-999) protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant MER (528-999) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Andere Bezeichnung: MER

Hintergrund:

Protein Background: MERTK (MER Proto-Oncogene, Tyrosine Kinase) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. MER regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, MERTK interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. Diseases associated with MERTK include Retinitis Pigmentosa 38 and Retinitis Pigmentosa.

Short Description: Recombinant MER(528-999) protein that includes amino acids 528-999 of human MER protein (accession number NP_006334.2) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 54 kDa.

Aliases: MER Proto-Oncogene Tyrosine Kinase, MERTK

Pathways: RTK Signalweg