SARS-CoV-2 Spike Protein (AA 910-988)

Produktnummer ABIN7669678

Dieses Recombinant SARS-CoV-2 Spike-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für SARS-CoV-2 Spike Protein (AA 910-988) (ABIN7669678)

Target: SARS-CoV-2 Spike

Protein-Typ: Recombinant

Biologische Aktivität: Inactive

Spezies: SARS Coronavirus-2 (SARS-CoV-2)

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 %

Produktdetails

Proteineigenschaft: AA 910-988

Verwendungszweck: Recombinant SARS-CoV-2 S Protein HR1

Sequenz: Gly910-Glu988

Sterilität: 0.2 μm filtered

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: SARS-CoV-2 Spike

Andere Bezeichnung: SARS-CoV-2 S

Substanzklasse: Viral Protein

Hintergrund: The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, dipeptidyl peptidase-4, APN, aminopeptidase N, CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1, Sia, sialic acid, O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion, Defines the range of the hosts and specificity of the virus, Main component to bind with the neutralizing antibody, Key target for vaccine design, Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.,SARS-CoV-2 Spike,SARS-CoV-2 Spike Protein

Molekulargewicht:

calculated_mw: 8.4 kDa

observed_mw: 8 kDa

UniProt: P0DTC2