Ras Protein-Specific Guanine Nucleotide-Releasing Factor 2 (RASGRF2) (AA 1-1189) protein (His tag)

Produktnummer ABIN7563527

Produktdetails

Target: Ras Protein-Specific Guanine Nucleotide-Releasing Factor 2 (RASGRF2)

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-1189

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: His tag

Verwendungszweck: Made-to-order recombinant Rasgrf2 Protein expressed in mammalian cells.

Sequenz: MQKSVRYNEG HALYLAMLAR KEGTKRGFLS KKAAEASRWH EKWFALYQNV LFYFEGEQSG RPAGMYLLEG CSCERTPAPP RTNAGPAGAR DALDKQYYFT VLFGHDGQKP LELRCEEEQA GKEWMEAIHQ ASYADILIER EVLMQKYIHL VQIVETEKIA TNQLRHQLED QDTEIERLKS EIVALNKTKE RMRPYHVHQE EEDPDIKKIK KVQSFMRGWL CRRKWKTIVQ DYICSPHAES MRKRNQIVFT MVEAETEYVH QLYILVNGFL RPLRMAASSK KPPINHDDVS SIFLNSETIM FLHEIFHQGL KARLANWPTL VLADLFDILL PMLNIYQEFV RNHQYSLQVL ANCKQNRDFD KLLKQYEANP ACEGRMLETF LTYPMFQIPR YIITLHELLA HTPHEHVERK SLEFAKSKLE ELSRVMHDEV SDTENIRKNL AIERMIVEGC DILLDTSQTF IRQGSLIQVP SVERGKLSKV RLGSLSLKKE GERQCFLFTK HFLICTRSSG GKLHLLKTGG VLSLIQCTLI EEPDGSDDDP KGSGHMFGHL DFKIVVEPPD AASFTVVLLA PSRQEKAAWM SDISQCVDNI RCNGLMTIVF EENSKVTVPH MIKSDARLHK DDTDICFSKT LNSCKVPQIR YASVERLLER LTDLRFLSID FLNTFLHTYR IFTTATVVLA KLSDIYKRPF TSIPVRSLEL FFATSQNNRE HLVDGKSPRL CRKFSSPPPL AVSRTSSPVR ARKLSLTSSL NSRIGALDLT NSSSSSSPTT TTHSPAASPP PHTAVLESAP ADKAGDSADM SPCRSPTTPR HLRYRQPGGQ VADSAHCSVS PASAFAIATA AAGHGSPPGF NNERTCDKEF IIRRTATNRV LNVLRHWVSK HAQDFELNNE LKMNVLNLLE EVLRDPDLLP QERKATANIL RALSQDDQDD IHLKLEDIIQ MTDCPKAECF ETLSAMELAE QITLLDHIVF RSIPYEEFLG QGWMKLDKNE RTPYIMKTSQ HFNEMSNLVA SQIMNYADIS SRANAIEKWV AVADICRCLH NYNGVLEITS ALNRSAIYRL KKTWAKVSKQ TKALMDKLQK TVSSEGRFKN LRETLKNCNP PAVPYLGMYL TDLAFIEEGT PNFTEEGLVN FSKMRMISHI IREIRQFQQT AYRIDQQPKV IQYLLDKALV IDEDSLYELS LKIEPRLPA Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Spezifität: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Produktmerkmale: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Reinheit: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Güteklasse: custom-made

Anwendungsinformationen

Applikationshinweise: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C.

Haltbarkeit: 12 months

Antigendetails

Target: Ras Protein-Specific Guanine Nucleotide-Releasing Factor 2 (RASGRF2)

Andere Bezeichnung: Rasgrf2 (RASGRF2 Produkte)

Hintergrund: Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2),FUNCTION: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:10733575, ECO:0000269|PubMed:11500499, ECO:0000269|PubMed:14749369, ECO:0000269|PubMed:15029245, ECO:0000269|PubMed:16407208, ECO:0000269|PubMed:16467520, ECO:0000269|PubMed:9032266, ECO:0000269|PubMed:9707409}.

Molekulargewicht: 135.7 kDa

UniProt: P70392

AlphaFold: P70392

Pathways: Neurotrophin Signalübertragung