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SP100 Protein (AA 1-482) (His tag)

custom-made SP100 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Produktnummer ABIN7562382
  • Target Alle SP100 Proteine anzeigen
    SP100 (SP100 Nuclear Antigen (SP100))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 1-482
    Spezies
    • 4
    • 2
    • 1
    • 1
    Maus
    Quelle
    • 5
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses SP100 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Predefined custom protein recombinant Sp100 Protein expressed in mammalian cells.
    Sequenz
    MEGSDGSPRM STEQENTEMH LIECMLKHFK TQKVAISNAI RSTFPFLESL RDHEFITGKM YEDLLDSCRS LVPVDKVIYR ALEELEKKFD MTVLCELFNE VNMEKYPDLN LIRRSFGCVF PNELCFQGID GGNPNSQLSL EQGPGASYSQ GSPNGSSLDL SASEGWRSND RRNSNLMQAN QTENHQLAES PGHLDSCELQ VQLNNRDATP ESCSLLPQNE ERAVQLNYEL QINPCFVQLV DVKKENSSFS LAGNQQTRAR TNQNEDSEII ELSSGDSDNG ENFSEATTTV PSQPAPAYSR KPPTLRRDRG GDTSDTESSI IIRRRKRTGR KKRERLGSYL IRNIKIPMKP SWKTAFLARS ANPSSQRRRK RGPRIPREEN ADFGGAELPV VCGNAQGFLD KEKFKQGIYV RSIRGKTGRL FTPMDFEIEG NCEKAKNWRQ SIRCKGWTLR ELIQKGVLQD PPRKKKETPR NPRQTRRQVN AL Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
    Spezifität
    If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
    Produktmerkmale
    Key Benefits:
    • Predefined custom protein - from design to production - by highly experienced protein experts.
    • Protein expressed in mammalian cells and purified in one-step affinity chromatography
    • The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
    • State-of-the-art algorithm used for plasmid design (Gene synthesis).
    This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

    If you are not interested in a full length protein, please contact us for individual protein fragments.

    The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
    Reinheit
    > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
    Güteklasse
    custom-made
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    Produkt
    Expressionssystem
    Konjugat
    Origin
    Preis
    Expressionssystem Escherichia coli (E. coli)
    Konjugat His tag
    Origin Mouse
    Preis 916,43 €
    Expressionssystem Yeast
    Konjugat His tag
    Origin Mouse
    Preis 4.034,80 €

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  • Applikationshinweise
    We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    The buffer composition is at the discretion of the manufacturer.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C.
    Haltbarkeit
    12 months
  • Target
    SP100 (SP100 Nuclear Antigen (SP100))
    Andere Bezeichnung
    Sp100 (SP100 Produkte)
    Hintergrund
    Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa),FUNCTION: Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. May also play a role in infection by viruses through mechanisms that may involve chromatin and/or transcriptional regulation (By similarity). {ECO:0000250|UniProtKB:P23497}.
    Molekulargewicht
    54.7 kDa
    UniProt
    O35892
    AlphaFold
    O35892
    Pathways
    Retinoic Acid Receptor Signaling Pathway
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