Complement Factor H Protein (CFH) (AA 19-1231) (His tag)

Produktnummer ABIN7538204

Dieses Recombinant Complement Factor H-Protein wird in Mammalian Cells produziert.

Kurzübersicht für Complement Factor H Protein (CFH) (AA 19-1231) (His tag) (ABIN7538204)

Target: Complement Factor H (CFH)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Mammalian Cells

Reinheit: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Produktdetails

Proteineigenschaft: AA 19-1231

Aufreinigungstag / Konjugat: Dieses Complement Factor H Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant human CFH Protein with C-terminal 10xHis tag

Spezifität: CFH (Glu19-Arg1231) 10xHis tag

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: Complement Factor H (CFH)

Andere Bezeichnung: CFH

Hintergrund: This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]

Molekulargewicht: predicted molecular mass of 138.4 kDa after removal of the signal peptide. The apparent molecular mass of CFH-His is 130-250 kDa due to glycosylation.

UniProt: P08603

Pathways: Komplementsystem, Cellular Response to Molecule of Bacterial Origin