RSPO1 Protein (His tag)

Produktnummer ABIN7536498

Dieses Recombinant RSPO1-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für RSPO1 Protein (His tag) (ABIN7536498)

Target: RSPO1 (R-Spondin 1 (RSPO1))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 97 % by SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses RSPO1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse R-spondin-1/RSPO1 Protein

Sequenz: SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCQEALYL HKGRCYPACP EGSTAANSTM ECGSPAQCEM SEWSPWGPCS KKRKLCGFRK GSEERTRRVL HAPGGDHTTC SDTKETRKCT VRRTPCPEGQ KRRKGGQGRR ENANRHPARK NSKEPRSNSR RHKGQQQPQP GTTGPLTSVG PTWAQ

Spezifität: Ser21-Gln265

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 0.01EU/μg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Konzentration: 0.47 mg/mL

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Antigendetails

Target: RSPO1 (R-Spondin 1 (RSPO1))

Andere Bezeichnung: R-spondin-1/RSPO1

Hintergrund:

Description: RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.

Name: Rspondin, R-spondin,RSPO1

Gen-ID: 192199

UniProt: Q9Z132