CD276 Protein (CD276) (His tag)

Produktnummer ABIN7536181

Dieses Recombinant CD276-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für CD276 Protein (CD276) (His tag) (ABIN7536181)

Target: CD276

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 97 % by SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD276 Protein ist gelabelt mit His tag.

Verwendungszweck: Active Recombinant Mouse CD276 Protein

Sequenz: VEVQVSEDPV VALVDTDATL RCSFSPEPGF SLAQLNLIWQ LTDTKQLVHS FTEGRDQGSA YSNRTALFPD LLVQGNASLR LQRVRVTDEG SYTCFVSIQD FDSAAVSLQV AAPYSKPSMT LEPNKDLRPG NMVTITCSSY QGYPEAEVFW KDGQGVPLTG NVTTSQMANE RGLFDVHSVL RVVLGANGTY SCLVRNPVLQ QDAHGSVTIT GQPLTF

Spezifität: Val 29 - Phe 244

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: <0.1EU/μg

Biological Activity Comment: Measured by its binding ability in a functional ELISA.Immobilized Mouse CD276 at 2 μg/mL (100 μL/well) can bind CD276 Rabbit pAb with a linear range of 1-274 ng/mL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Antigendetails

Target: CD276

Andere Bezeichnung: CD276

Hintergrund:

Description: B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.

Name: B7h3, B7RP-2, 6030411F23Rik,CD276

Gen-ID: 102657

UniProt: Q8VE98

Pathways: Cancer Immune Checkpoints