NOG Protein (AA 28-232)

Produktnummer ABIN7504481

Recombinant NOG-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für NOG Protein (AA 28-232) (ABIN7504481)

Target: NOG (Noggin (NOG))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Produktdetails

Proteineigenschaft: AA 28-232

Verwendungszweck: Mouse Noggin Protein

Sequenz: Gln28-Cys232

Produktmerkmale: Recombinant Mouse Noggin Protein is expressed from HEK293 without tag.It contains Gln28-Cys232.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 0.1 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS, 100 mM L-arginine ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: NOG (Noggin (NOG))

Andere Bezeichnung: Noggin

Hintergrund: Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β-catenin, EGFR, ERK and Akt.

Molekulargewicht: 23.07 kDa. Due to glycosylation, the protein migrates to 28-33 kDa based on Tris-Bis PAGE result.

UniProt: P97466

Pathways: Stem Cell Maintenance, Tube Formation