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Noggin (NOG) (AA 28-232) protein (Fc Tag) Protein

NOG Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Pubmed (1 reference)
Produktnummer ABIN2181545
$374.00
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  • Target Alle NOG Proteine anzeigen
    NOG
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 28-232
    Spezies
    • 10
    • 10
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Quelle
    • 21
    • 4
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses NOG Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 28-232
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.8 kDa. The protein migrates as 58-62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 100 mM Glycine, pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Ye, Ge, Zhang, Cheng, Zhang, He, Wang, Lin, Yang, Liu, Zhao, Deng: "Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds." in: Cell research, Vol. 26, Issue 1, pp. 34-45, (2016) (PubMed).

  • Target
    NOG
    Andere Bezeichnung
    Noggin (NOG Produkte)
    Synonyme
    SYM1, SYNS1, nog-A, nog1, noggin-1, noggin, noggin, noggin L homeolog, noggin protein, NOG, Nog, nog.L, noggin
    Hintergrund
    Noggin is also known as NOG,SYM1, SYNS1 and is a secreted homodimeric glycoprotein whose scaffold contains a cystine-knot topology similar to that of BMPs.Secreted Noggin probably remains close to the cell surface due to its binding of heparincontaining proteoglycans.Noggin inhibits TGF-β signal transduction by binding to TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion. During embryogenesis, Noggin antagonizes specific BMPs at defined times, for example, during neural tube, somite and cardiomyocyte growth and patterning. During skeletal development, Noggin prevents chondrocyte hyperplasia, thus allowing proper formation of joints. During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons Noggin also appears to maintain adult stem cell populations in vivo, for example, maintaining neural stem cells within the hippocampus.
    Molekulargewicht
    49.2 kDa
    NCBI Accession
    NP_005441
    Pathways
    Stem Cell Maintenance, Tube Formation
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