Claudin 4 Protein-VLP (CLDN4) (AA 1-209)

Produktnummer ABIN7504302

Produktdetails

Target: Claudin 4 (CLDN4)

Protein-Typ: VLP

Proteineigenschaft: AA 1-209

Spezies: Human

Quelle: HEK-293 Cells

Verwendungszweck: Human Claudin 4 Protein-VLP

Sequenz: Met1-Val209

Produktmerkmale: Recombinant Human Claudin 4 Protein-VLP is expressed from HEK293.It contains Met1-Val209.

Reinheit: > 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as 0.22μm filtered solution in PBS, 300 mM L-Arginine ( pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant.

Lagerung: -80 °C

Informationen zur Lagerung: Valid for 12 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Claudin 4 (CLDN4)

Andere Bezeichnung: Claudin 4 (CLDN4 Produkte)

Hintergrund: Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.

Molekulargewicht: 23.31 kDa.

UniProt: O14493

Pathways: Hepatitis C