TNFSF15 Protein

Produktnummer ABIN7488820

Dieses Recombinant TNFSF15-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für TNFSF15 Protein (ABIN7488820)

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: 90 %

Produktdetails

Verwendungszweck: Human TL1A / TNFSF15 Protein, His Tag

Sequenz: Met 1 - Leu 192

Produktmerkmale: Human TL1A Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Met 1 - Leu 192 (Accession # O95150-2).

Endotoxin-Niveau: 1.0 EU per μg

Anwendungsinformationen

Kommentare:

This protein carries a polyhistidine tag at the N-terminus. () The protein has a calculated MW of 23.7 kDa. The protein migrates as 30 kDa and 31-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Andere Bezeichnung: TL1A

Hintergrund: TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.

Molekulargewicht: 23.7 kDa

Pathways: Positive Regulation of Endopeptidase Activity, Autophagie