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Adenosine A2a Receptor Protein-VLP (ADORA2A) (AA 1-412)

Dieses VLP Adenosine A2a Receptor-Protein wird in HEK-293 Cells produziert.
Produktnummer ABIN7448150

Kurzübersicht für Adenosine A2a Receptor Protein-VLP (ADORA2A) (AA 1-412) (ABIN7448150)

Target

Alle Adenosine A2a Receptor (ADORA2A) Proteine anzeigen
Adenosine A2a Receptor (ADORA2A)

Protein-Typ

VLP

Biologische Aktivität

Active

Spezies

  • 13
  • 2
Human

Quelle

  • 7
  • 3
  • 2
  • 2
  • 1
HEK-293 Cells

Applikation

ELISA, Immunogen (Imm), Surface Plasmon Resonance (SPR), Functional Studies (Func)

Reinheit

> 95 % as determined by HPLC
  • Proteineigenschaft

    AA 1-412

    Verwendungszweck

    Human A2AR Protein-VLP

    Sequenz

    Met1-Ser412

    Produktmerkmale

    Recombinant Human A2AR Protein-VLP is expressed from HEK293.It contains Met1-Ser412.

    Sterilität

    0.22 μm filtered

    Endotoxin-Niveau

    Less than 1EU per μg by the LAL method.

    Biological Activity Comment

    Immobilized Human A2AR VLP at 10μg/ml (100μl/Well) on the plate. Dose response curve for Anti-A2AR Antibody, hFc Tag with the EC50 of 0.87μg/ml determined by ELISA.
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    Produkt
    Expressionssystem
    Konjugat
    Origin
    Preis ab
    Expressionssystem HEK-293 Cells
    Konjugat His tag
    Origin Human
    Preis ab 17.347,73 €
    Expressionssystem Cell-free protein synthesis (CFPS)
    Konjugat Strep Tag
    Origin Human
    Preis ab 20.480,57 €

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  • Applikationshinweise

    • Antibody Discovery: Immunization, Screening, Functional Characterization
    • Affinity determination: ELISA, SPR
    • In vivo pharmacokinetic analysis
    • CMC method development
    • CAR-T Positive Rate Detection
    • Blood sample determination: ELISA

    Kommentare

    Virus-like particles (VLPs) are formed from the outer capsid protein of a virus and are tiny nanoparticles formed by the automatic assembly of one or more capsid proteins. VLPs do not contain viral infectious genomes, so they are relatively safe during production operations. The SAMS™ protein engineering platform has been used to express a series of biotinylated, non-biotinylated, and fluorescently-labeled VLP-displayed antigens. They are suitable for SPR, ELISA, CAR-T positive rate detection, and other experimental scenarios.

    Virus-Like Particles (VLPs) are highly immunogenic, meaning that they can elicit a strong immune response in the host. VLPs are recognized by the immune system and are taken up by antigen-presenting cells (APCs) such as dendritic cells. Once taken up by APCs, VLPs are processed and presented to T cells, which can trigger the activation of B cells to produce antibodies against the displayed antigen. Because VLPs resemble the structure and composition of native viruses, they are highly effective at inducing both humoral and cellular immune responses.

    Generally, VLPs range in size from approximately 20 to 200 nanometers (nm). Compared to a cell-based immunization approach, their smaller size can optimize the immune response to target the specific antigen displayed on the surface of the engineered VLPs.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Supplied as 0.22μm filtered solution in PBS ( pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant.

    Lagerung

    -80 °C

    Informationen zur Lagerung

    Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Adenosine A2a Receptor (ADORA2A)

    Andere Bezeichnung

    A2AR

    Hintergrund

    Adenosine is a neuromodulator in the adult central nervous system. Membrane-bound receptors for adenosine have been identified and cDNAs for A1, A2a, A2b, and A3 adenosine receptor subtypes have been cloned recently.Expression of A2a adenosine receptor mRNA in cranial ganglia, carotid body, and intermediate lobe of the pituitary gland similarly suggests novel sites of adenosine action during development and in the adult.

    Molekulargewicht

    45.5 kDa.

    UniProt

    P29274

    Pathways

    Neurotrophin Signalübertragung, cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour, Cancer Immune Checkpoints
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