TRAIL Protein (AA 114-281)

Produktnummer ABIN7275774

Produktdetails

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Protein-Typ: Recombinant

Proteineigenschaft: AA 114-281

Spezies: Human

Quelle: Escherichia coli (E. coli)

Verwendungszweck: Human TRAIL/TNFRSF10 Protein

Sequenz: Val114-Gly281

Produktmerkmale: Recombinant Human TRAIL/TNFRSF10 Protein is expressed from E.coli without tag.It contains Val114-Gly281.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human TRAIL at 2μg/ml (100μl/well) on the plate. Dose response curve for Human TRAIL R1, hFc Tag with the EC50 of 51.6ng/ml determined by ELISA. The affinity constant of 0.57 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as 0.22μm filtered solution in 50 mM Tris, 300 mM NaCl ( pH 7.2).

Lagerung: -80 °C

Informationen zur Lagerung: Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Andere Bezeichnung: TRAIL (TNFSF10 Produkte)

Hintergrund: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents.

Molekulargewicht: 19.6 kDa same as Tris-Bis PAGE result.

NCBI Accession: NP_003801

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity