PVRIG Protein (AA 41-171) (Fc Tag)

Produktnummer ABIN7275504

Produktdetails

Target: PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))

Protein-Typ: Recombinant

Proteineigenschaft: AA 41-171

Spezies: Cynomolgus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PVRIG Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Cynomolgus PVRIG Protein

Sequenz: Thr41-Asp171

Produktmerkmale: Recombinant Cynomolgus PVRIG Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Thr41-Asp171.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Cynomolgus PVRIG, hFc Tag at 0.1μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Anti-PVRIG Antibody, hFc Tag with the EC50 of 5.4ng/ml determined by ELISA. The affinity constant of 0.23 μM as determined in SPR assay (Biacore T200). See testing image for detail.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))

Andere Bezeichnung: PVRIG (PVRIG Produkte)

Hintergrund: PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.PVRIG is a cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.

Molekulargewicht: 40.3 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.