PD-L1 Protein (AA 19-238) (His tag,Biotin)
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- Target Alle PD-L1 Proteine anzeigen
- PD-L1 (CD274 (PD-L1))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 19-238
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Spezies
- Maus
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses PD-L1 Protein ist gelabelt mit His tag,Biotin.
- Verwendungszweck
- Biotinylated Mouse PD-L1/B7-H1 Protein (Primary Amine Labeling)
- Sequenz
- Phe19-Thr238
- Produktmerkmale
- Recombinant Biotinylated Mouse PD-L1/B7-H1 Protein (Primary Amine Labeling) is expressed from HEK293 with His tag at the C-Terminus.It contains Phe19-Thr238.
- Reinheit
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterilität
- 0.22 μm filtered
- Endotoxin-Niveau
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- The affinity constant of 3.06 μM as determined in SPR assay (Biacore T200). See testing image for detail.
- Top Product
- Discover our top product PD-L1 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- PD-L1 (CD274 (PD-L1))
- Andere Bezeichnung
- PD-L1 (PD-L1 Produkte)
- Hintergrund
- B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance.
- Molekulargewicht
- 25.9 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Tris-Bis PAGE result.
- NCBI Accession
- NP_068693
- Pathways
- Cancer Immune Checkpoints
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