LGMN Protein (AA 18-435) (His tag)

Produktnummer ABIN7275145

Dieses Recombinant LGMN-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für LGMN Protein (AA 18-435) (His tag) (ABIN7275145)

Target: LGMN (Legumain (LGMN))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by Tris-Bis PAGE

Produktdetails

Proteineigenschaft: AA 18-435

Aufreinigungstag / Konjugat: Dieses LGMN Protein ist gelabelt mit His tag.

Verwendungszweck: Mouse LGMN Protein

Sequenz: Val18-Tyr435

Produktmerkmale: Recombinant Mouse LGMN Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Val18-Tyr435.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as 0.22μm filtered solution in PBS ( pH 7.4).

Lagerung: -80 °C

Informationen zur Lagerung: Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: LGMN (Legumain (LGMN))

Andere Bezeichnung: LGMN

Hintergrund: Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.

Molekulargewicht: 48.6 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Tris-Bis PAGE result.

UniProt: O89017

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades