GM-CSF Protein (AA 18-144)
Kurzübersicht für GM-CSF Protein (AA 18-144) (ABIN7274780)
Target
Alle GM-CSF (CSF2) Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
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Proteineigenschaft
- AA 18-144
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Verwendungszweck
- Human GM-CSF Protein
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Sequenz
- Ala18-Glu144
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Produktmerkmale
- Recombinant Human GM-CSF Protein is expressed from E.coli without tag.It contains Ala18-Glu144.
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Sterilität
- 0.22 μm filtered
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Endotoxin-Niveau
- Less than 0.1 EU per μg by the LAL method.
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Biological Activity Comment
- Immobilized Human GM-CSF at 2μg/ml (100μl/Well) on the plate. Dose response curve for Human GM-CSF R alpha, hFc Tag with the EC50 of 18.5ng/ml determined by ELISA. The affinity constant of 0.79nM as determined in SPR assay (Biacore T200). See testing image for detail.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
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Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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Haltbarkeit
- 12 months
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- GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))
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Andere Bezeichnung
- GM-CSF
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Hintergrund
- Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.
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Molekulargewicht
- 14.6 kDa same as Tris-Bis PAGE result.
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UniProt
- P04141
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Pathways
- JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin
Target
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