IgG2 Fc protein (Fc Tag)

Produktnummer ABIN7211742

Produktdetails

Target: IgG2 Fc

Protein-Typ: Recombinant

Spezies: Human

Quelle: Mammalian Cells

Aufreinigungstag / Konjugat: Fc Tag

Applikation: In vivo Studies (in vivo), Isotype Control (IsoC)

Verwendungszweck: In Vivo Grade Recombinant Human IgG2 Fc Protein

Produktmerkmale: Human Fc (IgG2) is the tail region of an immunoglobulin G2 (IgG2) that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. The ~230 amino acid fragment generally exists as a dimer, although under reducing conditions, it exists as a monomer. It is the basis of prolonged pharmacokinetics of antibodies and is commonly used as a fusion to extend half-life of fusion proteins. IgG2 has a shorter hinge than IgG1, with 12 amino acid residues and four disulfide bridges at the Fab base. The hinge region of IgG2 also lacks a glycine residue, which along with its shortness almost completely prevents rotation and restricts lateral movement of the Fabs.

Reinheit: > 95 %

Sterilität: Sterile filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg)

Güteklasse: In vivo Grade

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: 1 month from date of receipt, 2 to 8°C as supplied. 3 months from date of receipt, -20°C to -70°C as supplied.

Haltbarkeit: 3 months

Antigendetails

Target: IgG2 Fc