APOA1 Protein (His tag)

Produktnummer ABIN7319697

Dieses Recombinant APOA1-Protein wird in Human Cells produziert.

Kurzübersicht für APOA1 Protein (His tag) (ABIN7319697)

Target: APOA1 (Apolipoprotein A-I (APOA1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses APOA1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Apolipoprotein A-I/ApoAI Protein (aa 19-267, His Tag)

Sequenz: Arg19-Gln267

Produktmerkmale: Recombinant Human Apolipoprotein A-I is produced by our Mammalian expression system and the target gene encoding Arg19-Gln267 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Kommentare:

30 kDa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: APOA1 (Apolipoprotein A-I (APOA1))

Andere Bezeichnung: Apolipoprotein A-I

Hintergrund:

Background: Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes, such as Cholesterol metabolism, Lipid metabolism and transport, Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies, including Tangier disease (TGD), systemic non-neuropathic amyloidosis, premature coronary artery disease, hepatosplenomegaly and progressive muscle wasting and weakness. In addition, ApoA-I is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.

Synonym: Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1, APOA1

Molekulargewicht: 30 kDa

UniProt: P02647

Pathways: Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism