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FGF8 Protein

This anti-FGF8 antibody (ABIN7198878) is a Escherichia coli (E. coli) antibody detecting FGF8 in . Suitable for Human.
Produktnummer ABIN7198878

Kurzübersicht für FGF8 Protein (ABIN7198878)

Target

Alle FGF8 Proteine anzeigen
FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 11
  • 3
  • 2
  • 1
  • 1
Human

Quelle

  • 16
  • 2
Escherichia coli (E. coli)

Reinheit

> 95 % as determined by reducing SDS-PAGE.
  • Verwendungszweck

    Recombinant Human FGF8a/FGF-8a Protein (Active)

    Sequenz

    Gln23-Arg204

    Produktmerkmale

    A DNA sequence encoding the human FGF8a (NP_149355.1) (Gln23-Arg204) was expressed with an initial Met.

    Endotoxin-Niveau

    Please contact us for more information.

    Biological Activity Comment

    Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.8-3.3 μg/mL.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.5

    Lagerung

    4 °C,-20 °C,-80 °C

    Informationen zur Lagerung

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))

    Andere Bezeichnung

    FGF8a

    Hintergrund

    Background: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.

    Synonym: AIGF,FGF-8,HBGF-8,HH6,KAL6

    Molekulargewicht

    21.3 kDa

    NCBI Accession

    NP_149355

    Pathways

    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Dopaminergic Neurogenesis
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