CD27 Protein (His tag)

Produktnummer ABIN7321004

Dieses Recombinant CD27-Protein wird in Human Cells produziert.

Kurzübersicht für CD27 Protein (His tag) (ABIN7321004)

Target: CD27 (CD27 Molecule (CD27))

Protein-Typ: Recombinant

Spezies: Rhesusaffen

Quelle: Human Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD27 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Rhesus macaque CD27/TNFRSF7 Protein (His Tag)

Sequenz: Thr21-Ile192

Produktmerkmale: Recombinant Rhesus macaque CD27 is produced by our Mammalian expression system and the target gene encoding Thr21-Ile192 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Kommentare:

40 kDa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CD27 (CD27 Molecule (CD27))

Andere Bezeichnung: CD27/TNFRSF7

Hintergrund:

Background: CD27 antigen, also known as CD27L receptor, T-cell activation antigen CD27, T14, S152, Tp55, TNFRSF7 and Tumor necrosis factor receptor for superfamily member 7,belongs to the TNF-receptor superfamily. CD27 is a single-pass type I membrane protein and exists as a homodimer form, containing three TNFR-Cys repeats. CD27 transduces signals that lead to the activation of NF-KappaB and MAPK8/JNK. CD27 is involved in regulating B-cell activation and immunoglobulin synthesis, binding to the ligand CD70. TRAF2 and TRAF5 have been shown to mediate the signaling process of CD27. CD27-binding protein (SIVA), which is a proapoptotic protein, can bind to CD27 and is thought to play a key role in the apoptosis. CD27 is required for generation and long-term maintenance of T cell immunity.

Synonym: CD27 Antigen, CD27L Receptor, T-Cell Activation Antigen CD27, T14, Tumor Necrosis Factor Receptor Superfamily Member 7, CD27, CD27, TNFRSF7

Molekulargewicht: 20.1 kDa

UniProt: F7BYS2

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints