FAS Protein (Fc Tag)

Produktnummer ABIN7320851

Dieses Recombinant FAS-Protein wird in Human Cells produziert.

Kurzübersicht für FAS Protein (Fc Tag) (ABIN7320851)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses FAS Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Mouse FAS/TNFRSF6 Protein (Fc Tag)

Sequenz: Gln22-Arg169

Produktmerkmale: Recombinant Mouse FAS is produced by our Mammalian expression system and the target gene encoding Gln22-Arg169 is expressed with a Fc tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Andere Bezeichnung: FAS/TNFRSF6

Hintergrund:

Background: Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Synonym: Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor,CD95,Fas,TNFRSF6

Molekulargewicht: 43.7 kDa

UniProt: P25446

Pathways: p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity