STXBP3 Protein (His-GST)

Produktnummer ABIN7317481

Dieses Recombinant STXBP3-Protein wird in Baculovirus infected Insect Cells produziert.

Kurzübersicht für STXBP3 Protein (His-GST) (ABIN7317481)

Target: STXBP3 (Syntaxin Binding Protein 3 (STXBP3))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Reinheit: > 82 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses STXBP3 Protein ist gelabelt mit His-GST.

Verwendungszweck: Recombinant Human STXBP3/UNC-18C Protein (His & GST Tag)

Sequenz: Met 1-Glu 592

Produktmerkmale: A DNA sequence encoding the human STXBP3 (O00186-1) (Met 1-Glu 592) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.5, 10 % glycerol
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: STXBP3 (Syntaxin Binding Protein 3 (STXBP3))

Andere Bezeichnung: STXBP3/UNC-18C

Hintergrund: MUNC18-3,MUNC18C,PSP,UNC-18C,Syntaxin-binding protein 3, also known as Platelet Sec1 protein, Protein unc-18 homolog 3, Protein unc-18 homolog C, Unc-18C, Unc18-3 and STXBP3, is a cytoplasm protein which belongs to theSTXBP/unc-18/SEC1 family. STXBP3 is expressed in cells that exhibit granule exocytosis, such as neutrophils, mast cells, platelets and endothelial cells. STXBP3, together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking / fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. STXBP3 participates in the consolidation and secretion of secondary and tertiary granules. STXBP3 contains one SEC1 domain. Phosphorylation at Ser129 may stimulate granule release. Human STXBP3 shares 90 % aa identity with mouse STXBP3. STXBP3 interacts with DOC2B, the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion. Interacts with STX4.

Molekulargewicht:

Calculated MW: 95.6 kDa

Observed MW: 95.6 kDa

Gen-ID: 6814

UniProt: O00186

Pathways: Hormone Transport