SPHK1 Protein

Produktnummer ABIN7317043

Dieses Recombinant SPHK1-Protein wird in Baculovirus infected Insect Cells produziert.

Kurzübersicht für SPHK1 Protein (ABIN7317043)

Target: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Produktdetails

Verwendungszweck: Recombinant Human SPHK1/Sphingosine Kinase 1 Protein (Active)

Sequenz: Met 1-Leu 384

Produktmerkmale: A DNA sequence encoding the human SPHK1 (Q9NYA1-1)(Met1-Leu384) was fused with two additional amino acids (Gly & Pro) at the N-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 1028 nmol/min/mg using Sphingosine Kinase Substrate as substrate.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Andere Bezeichnung: SPHK1/Sphingosine Kinase 1

Hintergrund:

Background: SPHK1, also known as sphingosine Kinase 1, catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It is a ligand for cell surface G protein-coupled receptors. SPHK 1 is a potential therapeutic target for the control of cancer and inflammation. SPHK1 plays a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes.

Synonym: SPHK,SPHK1,SPK

Molekulargewicht: 42.7 kDa

Pathways: VEGF Signaling