Sclerostin Protein (SOST) (His tag)

Produktnummer ABIN7197841

Dieses Recombinant Sclerostin-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für Sclerostin Protein (SOST) (His tag) (ABIN7197841)

Target: Sclerostin (SOST)

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: HEK-293 Cells

Reinheit: > 97 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses Sclerostin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Rat Sclerostin/SOST Protein (His Tag)

Sequenz: Met 1-Tyr 213

Produktmerkmale: A DNA sequence encoding the rat SOST (NP_085073.1) (Met 1-Tyr 213) was expressed, fused with a polyhistidine tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Sclerostin (SOST)

Andere Bezeichnung: Sclerostin/SOST

Hintergrund:

Background: Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation.

Synonym: SOST

Molekulargewicht: 23 kDa

NCBI Accession: NP_085073