PGC Protein (His tag)

Produktnummer ABIN7317422

Recombinant PGC-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für PGC Protein (His tag) (ABIN7317422)

Target: PGC (Pepsinogen C (PGC))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses PGC Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Pepsinogen C/PGC Protein (E.coli, His Tag)

Sequenz: Ile153-Ile239

Produktmerkmale: A DNA sequence encoding the mature form of human PGC (P20142-1) (Ile153-Ile239) was expressed with a polyhistide tag at the N-terminus.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 0.4M sucrose, 1 mM EDTA, 50 mM NaCl, pH 8.0

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PGC (Pepsinogen C (PGC))

Andere Bezeichnung: Pepsinogen C/PGC

Hintergrund:

Background: Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.

Synonym: PEPC,PGII

Molekulargewicht: 10.9 kDa