PGC Protein (His tag)

Produktnummer ABIN7197294

Produktdetails

Target: PGC (Pepsinogen C (PGC))

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PGC Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Rat Pepsinogen C/PGC Protein (His Tag)

Sequenz: Met 1-Val 392

Produktmerkmale: A DNA sequence encoding the rat PGC (NP_579818.1) (Met 1-Val 392) was expressed, fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 150 mM NaCl, pH 7.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PGC (Pepsinogen C (PGC))

Andere Bezeichnung: Pepsinogen C/PGC (PGC Produkte)

Synonyme: PEPC Protein, PGII Protein, 2210410L06Rik Protein, Upg-1 Protein, Upg1 Protein, CPGC Protein, gastricsin Protein, PG1 Protein, Pg-1 Protein, PGNC Protein, PGC Protein, Gastricsin Protein, progastricsin (pepsinogen C) Protein, progastricsin Protein, PGC Protein, Pgc Protein

Hintergrund:

Background: Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.

Synonym: PG1,Pg-1,Upg1

Molekulargewicht: 42.5 kDa

NCBI Accession: NP_579818