Neuroligin 1 Protein (NLGN1) (His tag)

Produktnummer ABIN7320172

Dieses Recombinant Neuroligin 1-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für Neuroligin 1 Protein (NLGN1) (His tag) (ABIN7320172)

Target: Neuroligin 1 (NLGN1)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 97 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses Neuroligin 1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Neuroligin 1/NLGN1 Protein (His Tag)

Sequenz: Met 1-Ser 697

Produktmerkmale: A DNA sequence encoding the mouse NLGN1 isoform 1 (Q99K10-1) extracellular domain (Met 1-Ser 697) was expressed, with a C-terminal polyhistidine tag.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Neuroligin 1 (NLGN1)

Andere Bezeichnung: Neuroligin 1/NLGN1

Hintergrund:

Background: Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. Neuroligins consist of five members (NLGN1, NLGN2, NLGN3, NLGN4 and NLGN4Y), which interact with beta-neurexins and this interaction is involved in the formation of functional synapses. The extracellular domain of functional Neuroligin 1 associates as a dimer when analyzed by sedimentation equilibrium. Neuroligin 1 has a unique N-linked glycosylation pattern in the neuroligin family, and glycosylation and its processing modify neuroligin activity. Neuroligin 1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. The persistent expression of Neuroligin 1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.

Synonym: 6330415N05Rik,BB179718,mKIAA1070,NL1,Nlg1

Molekulargewicht: 73.5 kDa

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis