NBL1 Protein (His tag)

Produktnummer ABIN7320621

Produktdetails

Target: NBL1 (Neuroblastoma 1, DAN Family BMP Antagonist (NBL1))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses NBL1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse NBL1/DAND1 Protein (His Tag)

Sequenz: Ala17-Asp178

Produktmerkmale: Recombinant Mouse Differential Screening-selected Gene Aberrant in Neuroblastoma is produced by our Mammalian expression system and the target gene encoding Ala17-Asp178 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: NBL1 (Neuroblastoma 1, DAN Family BMP Antagonist (NBL1))

Andere Bezeichnung: NBL1/DAND1 (NBL1 Produkte)

Hintergrund:

Background: Differential screening-selected gene aberrative in neuroblastoma (DAN) is a member of the DAN family of secreted glycoproteins. DAN family antagonists are characterized by a DAN domain that contains a cystine knot motif which is essential for binding to BMP ligands. Members of this family include DAN, gremlin, protein related to DAN and cerberus (PRDC), cerberus, sclerostin (SOST) and uterine sensitization-associated gene 1 protein, and control diverse processes in growth, development and the cell cycle. It has also been reported that DAN family plays crucial role in early mouse embryo development by inhibiting the action of bone morphogenic proteins and modulating the action of transforming growth factor-β superfamily members. DAN is synthesized by small-to intermediate-sized DRG neurons and transported to the sensory nerve terminals in the skin or to the sensory nerve terminals in the dorsal horn. It has been reported that DAN is ubiquitously expressed in adult rat and human tissues. Morphological studies have revealed that, in adult rat, DAN mRNA is expressed ubiquitously in lung and brain, but not in liver.

Synonym: DAND1, NBL1, DAN domain family member 1, neuroblastoma suppressor of tumorigenicity 1, Protein N03, suppression of tumorigenicity 1,DAN,Dana

Molekulargewicht: 18.4 kDa

UniProt: Q61477