Leptin Receptor Protein (LEPR) (Fc Tag)

Produktnummer ABIN7320922

Produktdetails

Target: Leptin Receptor (LEPR)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses Leptin Receptor Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Mouse Leptin Receptor/LEPR/CD295 (C-Fc)

Sequenz: Leu22-Gly839

Produktmerkmale: Recombinant Mouse Leptin Receptor is produced by our Mammalian expression system and the target gene encoding Leu22-Gly839 is expressed with a Fc tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Leptin Receptor (LEPR)

Andere Bezeichnung: Leptin Receptor/LEPR/CD295 (LEPR Produkte)

Hintergrund:

Background: The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WSXWS motif, a transmembrane domain, and a cytoplasmic domain that supports JAK/STAT signaling. Soluble Leptin R is the primary Leptin-binding protein in blood, where it maintains a pool of available bioactive Leptin, delays Leptin clearance from circulation, and down-regulates blood-brain transmission of Leptin. In humans, soluble Leptin R levels are inversely proportional to adiposity and are elevated in females versus males. Soluble Leptin R is also found up-regulated in patients with chronic heart failure, end-stage renal disease, and anorexia.It is expressed by tumor-initiating stem cells, and is proposed as a link between cancer and obesity.

Synonym: Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD295, LEPR, DB, OBR

Molekulargewicht: 119.1 kDa

UniProt: P48356

Pathways: JAK-STAT Signalweg, AMPK Signaling, Feeding Behaviour