IL-5 Protein (AA 20-134) (mFc Tag)

Produktnummer ABIN7319796

Recombinant IL-5-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für IL-5 Protein (AA 20-134) (mFc Tag) (ABIN7319796)

Target: IL-5 (IL5) (Interleukin 5 (IL5))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 20-134

Aufreinigungstag / Konjugat: Dieses IL-5 Protein ist gelabelt mit mFc Tag.

Verwendungszweck: Recombinant Human Interleukin-5/IL-5 (C-mFc)

Sequenz: Ile20-Ser134

Produktmerkmale: Recombinant Human Interleukin-5 is produced by our Mammalian expression system and the target gene encoding Ile20-Ser134 is expressed with a mFc tag at the C-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: IL-5 (IL5) (Interleukin 5 (IL5))

Andere Bezeichnung: Interleukin-5/IL-5

Hintergrund: Nterleukin,Interleukin,IL5,EDF,IL-5,TRF,BCDFII,B-cell differentiation factor I,B-cell growth factor I,BCGF-II,Cytotoxic T-lymphocyte inducer,E-CSF,Eosinophil differentiation factor,ESGF,Interleukin-5,nterleukin-5,T-cell replacing factor,IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cells and eosinophils. Relative to B cells, IL-5 appears to induce the differentiation of activated conventional B-2 cells into Ig-secreting cells. In addition, it induces the growth of B-1 progenitors as well as IgM production by B-1 cells.IL-5 appears to perform a number of functions on eosinophils. These include the down modulation of Mac-1,the upregulation of receptors for IgA and IgG,the stimulation of lipid mediator (leukotriene C4 and PAF) secretion and the induction of granule release.IL-5 also promotes the growth and differentiation of eosinophils.

Molekulargewicht:

Calculated MW: 39.8 kDa

Observed MW: 40-55 kDa

Gen-ID: 3567

UniProt: P05113

Pathways: JAK-STAT Signalweg, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Feeding Behaviour