IL12B Protein (AA 23-328)

Produktnummer ABIN7318099

Recombinant IL12B-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für IL12B Protein (AA 23-328) (ABIN7318099)

Target: IL12B (Interleukin 12 beta (IL12B))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 23-328

Verwendungszweck: Recombinant Human IL-12 p40/IL-12B Protein

Sequenz: Ile23-Ser328

Produktmerkmale: Recombinant Human Interleukin-12 subunit beta is produced by our Mammalian expression system and the target gene encoding Ile23-Ser328 is expressed.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: IL12B (Interleukin 12 beta (IL12B))

Andere Bezeichnung: IL-12 p40/IL-12B

Hintergrund: IL-12/IL-23 p,IL-12 subunit p,NK cell stimulatory factor chain,NK cell Stimulating Factor Chain,CLMF p,IMD,IL12B,CLMF,CLMF2,IL-12B,IMD28,IMD29,NKSF,NKSF2,Cytotoxic lymphocyte maturation factor 40 kDa subunit,Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40),IL-12/IL-23 p40,NK cell Stimulating Factor Chain 2,p40,Interleukin-12 subunit beta,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,IL 12B,IL12 p40,Interleukin 12 beta chain,Interleukin 12 p40,Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.

Molekulargewicht:

Calculated MW: 34.6 kDa

Observed MW: 40-47 kDa

Gen-ID: 3593

UniProt: P29460

Pathways: JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation