IL-11 Protein (AA 23-199)

Produktnummer ABIN7319568

Dieses Recombinant IL-11-Protein wird in Yeast (Pichia pastoris) exprimiert.

Kurzübersicht für IL-11 Protein (AA 23-199) (ABIN7319568)

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Yeast (Pichia pastoris)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 23-199

Verwendungszweck: Recombinant Human Interleukin-11/IL-11 Protein

Sequenz: Gly23-Leu199

Produktmerkmale: Recombinant Human Interleukin-11 is produced by our Yeast expression system and the target gene encoding Gly23-Leu199 is expressed.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 2 % Glycine, pH 7.2.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Andere Bezeichnung: Interleukin-11/IL-11

Hintergrund: Interleukin,Adipogenesis Inhibitory Factor,AGIF,AGIF (Adipogenesis Inhibitory Factor),IL-11,Interleukin-11,Oprelvekin,IL11,Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. It also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2, It activates a signaling cascade that promotes cell proliferation. The signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.

Molekulargewicht:

Calculated MW: 19.0 kDa

Observed MW: 19 kDa

Gen-ID: 3589

UniProt: P20809

Pathways: JAK-STAT Signalweg, Negative Regulation of Hormone Secretion