GNMT Protein (His tag)

Produktnummer ABIN7318543

Recombinant GNMT-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für GNMT Protein (His tag) (ABIN7318543)

Target: GNMT (Glycine N-Methyltransferase (GNMT))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses GNMT Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human GNMT Protein (His Tag)

Sequenz: Met 1-Asg294

Produktmerkmale: Recombinant Human Glycine N-Methyltransferase is produced by our E.coli expression system and the target gene encoding Met1-Asg294 is expressed with a 6His tag at the N-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: GNMT (Glycine N-Methyltransferase (GNMT))

Andere Bezeichnung: GNMT

Hintergrund:

Background: Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cause of hypermethioninemia. the patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.

Synonym: Glycine N-Methyltransferase, GNMT

Molekulargewicht: 34.9 kDa

UniProt: Q14749

Pathways: Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process