FRZB Protein (His tag)

Produktnummer ABIN7317893

Dieses Recombinant FRZB-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für FRZB Protein (His tag) (ABIN7317893)

Target: FRZB (Frizzled-Related Protein (FRZB))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses FRZB Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human FRZB/sFRP-3 Protein (His Tag)

Sequenz: Ala32-Asn325

Produktmerkmale: A DNA sequence encoding the human FRZB (NP_001454.2) (Ala32-Asn325) was expressed with a C-terminal polyhistidine tag.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: FRZB (Frizzled-Related Protein (FRZB))

Andere Bezeichnung: FRZB/sFRP-3

Hintergrund:

Background: FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis (OA) susceptibility. FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.

Synonym: FRE,FRITZ,FRP-3,FRZB-1,FRZB-PEN,FRZB1,FZRB,hFIZ,OS1,SFRP3,SRFP3

Molekulargewicht: 34.5 kDa

NCBI Accession: NP_001454

Pathways: WNT Signalweg, Positive Regulation of fat Cell Differentiation