Ezrin Protein (EZR) (AA 1-586)

Produktnummer ABIN7319618

Recombinant Ezrin-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für Ezrin Protein (EZR) (AA 1-586) (ABIN7319618)

Target: Ezrin (EZR)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 1-586

Verwendungszweck: Recombinant Human Ezrin/EZR Protein

Sequenz: Met1-Leu586

Produktmerkmale: Recombinant Human Ezrin is produced by our E.coli expression system and the target gene encoding Met1-Leu586 is expressed.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 10 mM HEPES, pH 7.4.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: Ezrin (EZR)

Andere Bezeichnung: Ezrin/EZR

Hintergrund: Cytovillin,EZR,Ezrin,VIL2,Villin-2,p81,Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskeletal structures to the plasma membrane. The N-terminal FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (NHERF) proteins (involving long-range allostery). The C-terminal binds to actin, phosphatidylinositol bis-phosphate (PIP2) and membrane proteins like CD44 and ICAM-2. In epithelial cells, Ezrin is required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, Ezrin is required for normal macropinocytosis.

Molekulargewicht:

Calculated MW: 69.4 kDa

Observed MW: 80 kDa

Gen-ID: 7430

UniProt: P15311

Pathways: Maintenance of Protein Location