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GM-CSF Protein

Dieses Recombinant GM-CSF-Protein wird in Escherichia coli (E. coli) exprimiert.
Produktnummer ABIN7320537

Kurzübersicht für GM-CSF Protein (ABIN7320537)

Target

Alle GM-CSF (CSF2) Proteine anzeigen
GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 32
  • 13
  • 12
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Maus

Quelle

  • 35
  • 9
  • 8
  • 5
  • 5
  • 4
  • 3
  • 1
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 95 % as determined by SDS-PAGE
  • Verwendungszweck

    Recombinant Mouse GM-CSF/CSF2 Protein (Active)

    Sequenz

    Ala18-Lys141

    Produktmerkmale

    Recombinant Mouse Granulocyte-Macrophage Colony-Stimulating Factor is produced by our E.coli expression system and the target gene encoding Ala18-Lys141 is expressed.

    Endotoxin-Niveau

    < 1.0 EU per μg as determined by the LAL method.

    Biological Activity Comment

    Measured in a cell proliferation assay using PDC-P1 cells The ED50 for this effect is 15-50 pg/ml.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

    Lagerung

    4 °C,-20 °C,-80 °C

    Informationen zur Lagerung

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

    Andere Bezeichnung

    GM-CSF/CSF2

    Hintergrund

    Background: Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factorthat can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by anumber of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cellsand fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophageprogenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. Onmature hematopoietic, monocytes/ macrophages and eosinophils. GM-CSF has a functional role on nonhematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF canalso stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma andadenocarcinoma cell lines.

    Synonym: Granulocyte-macrophage colony-stimulating factor,Csf2,GM-CSF,Colony-stimulating factor,Csfgm

    Molekulargewicht

    14.2 kDa

    UniProt

    P01587

    Pathways

    JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin
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