GM-CSF Protein
Kurzübersicht für GM-CSF Protein (ABIN7320537)
Target
Alle GM-CSF (CSF2) Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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Verwendungszweck
- Recombinant Mouse GM-CSF/CSF2 Protein (Active)
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Sequenz
- Ala18-Lys141
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Produktmerkmale
- Recombinant Mouse Granulocyte-Macrophage Colony-Stimulating Factor is produced by our E.coli expression system and the target gene encoding Ala18-Lys141 is expressed.
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Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- Measured in a cell proliferation assay using PDC-P1 cells The ED50 for this effect is 15-50 pg/ml.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
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Lagerung
- 4 °C,-20 °C,-80 °C
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Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))
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Andere Bezeichnung
- GM-CSF/CSF2
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Hintergrund
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Background: Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factorthat can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by anumber of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cellsand fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophageprogenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. Onmature hematopoietic, monocytes/ macrophages and eosinophils. GM-CSF has a functional role on nonhematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF canalso stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma andadenocarcinoma cell lines.
Synonym: Granulocyte-macrophage colony-stimulating factor,Csf2,GM-CSF,Colony-stimulating factor,Csfgm
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Molekulargewicht
- 14.2 kDa
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UniProt
- P01587
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Pathways
- JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin
Target
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