CD70 Protein (mFc Tag)

Produktnummer ABIN7319773

Recombinant CD70-Protein exprimiert in Human Cells.

Kurzübersicht für CD70 Protein (mFc Tag) (ABIN7319773)

Target: CD70 (CD70 Molecule (CD70))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Reinheit: >95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD70 Protein ist gelabelt mit mFc Tag.

Verwendungszweck: Recombinant Human CD27 Ligand/TNFSF7/CD70 (C-mFc)

Sequenz: Gln45-Pro193

Produktmerkmale: Recombinant Human CD27 Ligand/CD70 is produced by our Mammalian expression system and the target gene encoding Gln45-Pro193 is expressed with a mFc tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CD70 (CD70 Molecule (CD70))

Andere Bezeichnung: CD27 Ligand/TNFSF7/CD70

Hintergrund:

Background: CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular region is 64 % aa identical to mouse and rat CD27 Ligand extracellular regions. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Synonym: CD70 antigen, CD70, CD27 ligand, Tumor necrosis factor ligand superfamily member 7, CD27LG, TNFSF7, CD27L

Molekulargewicht: 43 kDa

UniProt: P32970

Pathways: Cancer Immune Checkpoints